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CPT1B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q92523 |
| Other Accession | NP_001138609.1, NP_001138607.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87801 Da |
| Antigen Region | 744-770 aa |
| Gene ID | 1375 |
|---|---|
| Other Names | Carnitine O-palmitoyltransferase 1, muscle isoform, CPT1-M, Carnitine O-palmitoyltransferase I, muscle isoform, CPT I, CPTI-M, Carnitine palmitoyltransferase 1B, Carnitine palmitoyltransferase I-like protein, CPT1B, KIAA1670 |
| Target/Specificity | This CPT1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 744-770 amino acids from the C-terminal region of human CPT1B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CPT1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CPT1B |
|---|---|
| Synonyms | KIAA1670 |
| Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein |
| Tissue Location | Strong expression in heart and skeletal muscle. No expression in liver and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene.
References
Matsuo, T., et al. Biochem. Genet. 48 (3-4), 193-201 (2010) :
Miljkovic, I., et al. Obesity (Silver Spring) 17(7):1396-1401(2009)
Miyagawa, T., et al. PLoS ONE 4 (4), E5394 (2009) :
van der Leij, F.R., et al. J. Biol. Chem. 277(30):26994-27005(2002)
Yamazaki, N., et al. J. Biol. Chem. 275(41):31739-31746(2000)
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