NACC2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q96BF6 |
Other Accession | NP_653254.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 62837 Da |
Antigen Region | 473-502 aa |
Gene ID | 138151 |
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Other Names | Nucleus accumbens-associated protein 2, NAC-2, BTB/POZ domain-containing protein 14A, Repressor with BTB domain and BEN domain, NACC2, BTBD14A, NAC2, RBB |
Target/Specificity | This NACC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-502 amino acids from the C-terminal region of human NACC2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NACC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NACC2 |
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Synonyms | BTBD14A, NAC2, RBB |
Function | Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. |
Cellular Location | Nucleus. Note=Predominantly associated with chromatin |
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Background
BTBD14A (BTB/POZ domain-containing protein 14A), also known as BTBD14, is a 587 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD14A may play a role in transcription regulation.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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