|Application ||WB, E|
|Other Accession||NP_057658.2, NP_000786.1|
|Calculated MW||50619 Da|
|Antigen Region||307-336 aa|
|Other Names||D(2) dopamine receptor, Dopamine D2 receptor, DRD2|
|Target/Specificity||This DRD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the C-terminal region of human DRD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DRD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
Verma, V., et al. J. Biol. Chem. 285(45):35092-35103(2010)
Borroto-Escuela, D.O., et al. Biochem. Biophys. Res. Commun. 401(4):605-610(2010)
Stelzel, C., et al. J. Neurosci. 30(42):14205-14212(2010)
Huang, H.Y., et al. J. Formos. Med. Assoc. 109(10):736-739(2010)
Itokawa, M., et al. J. Pharmacol. Sci. 114(1):1-5(2010)
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