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RFX1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P22670 |
| Other Accession | P48377, NP_002909.4 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 104758 Da |
| Antigen Region | 896-925 aa |
| Gene ID | 5989 |
|---|---|
| Other Names | MHC class II regulatory factor RFX1, Enhancer factor C, EF-C, Regulatory factor X 1, RFX, Transcription factor RFX1, RFX1 |
| Target/Specificity | This RFX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 896-925 amino acids from the C-terminal region of human RFX1. |
| Dilution | IF~~1:10~50 WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RFX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RFX1 |
|---|---|
| Function | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.
References
Zhao, M., et al. J. Autoimmun. 35(1):58-69(2010)
Purvis, T.L., et al. Gene 460 (1-2), 20-29 (2010) :
Hsu, Y.C., et al. J. Biol. Chem. 285(18):13885-13895(2010)
Seguin-Estevez, Q., et al. J. Immunol. 183(4):2545-2553(2009)
Zhang, Y., et al. Mol. Biol. (Mosk.) 43(1):77-84(2009)
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