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PLRG1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O43660 |
| Other Accession | Q9WUC8, Q922V4, Q2KID6, NP_002660.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57194 Da |
| Antigen Region | 17-45 aa |
| Gene ID | 5356 |
|---|---|
| Other Names | Pleiotropic regulator 1, PLRG1 |
| Target/Specificity | This PLRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human PLRG1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLRG1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLRG1 |
|---|---|
| Function | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). As a component of the minor spliceosome, involved in the splicing of U12- type introns in pre-mRNAs (Probable). |
| Cellular Location | Nucleus. Nucleus speckle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PLRG1 is necessary for spliceosome assembly and for pre-mRNA splicing.
References
Lleres, D., et al. EMBO Rep. 11(6):445-451(2010)
Dehghan, A., et al. Circ Cardiovasc Genet 2(2):125-133(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Ajuh, P., et al. Nucleic Acids Res. 31(21):6104-6116(2003)
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