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TRPC1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P48995 |
| Other Accession | Q9TUN9, Q61056, O18784, NP_003295.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 91212 Da |
| Antigen Region | 765-793 aa |
| Gene ID | 7220 |
|---|---|
| Other Names | Short transient receptor potential channel 1, TrpC1, Transient receptor protein 1, TRP-1, TRPC1, TRP1 |
| Target/Specificity | This TRPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 765-793 amino acids from the C-terminal region of human TRPC1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRPC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRPC1 |
|---|---|
| Synonyms | TRP1 |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11139478, PubMed:15016832, PubMed:39478185). Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Seems to be ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TRPC1 belongs to the transient receptor potential (TRP) superfamily of cation channels. TRP cation channels are involved in diverse physiologic processes, including receptor- and store-operated Ca(2+) entry, mineral absorption, and cell death. They also function as sensors for pain, heat, cold, sound, stretch, and osmotic changes (Zhang et al., 2009 [PubMed 19193631]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Bomben, V.C., et al. Glia 58(10):1145-1156(2010)
Lu, M., et al. J. Mol. Endocrinol. 44(5):285-294(2010)
Gonzalez-Cobos, J.C., et al. Front. Biosci. 15, 1023-1039 (2010) :
Ingueneau, C., et al. J. Cell. Mol. Med. 13 (8B), 1620-1631 (2009) :
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