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NHLH1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q02575 |
| Other Accession | NP_005589.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 14618 Da |
| Antigen Region | 38-67 aa |
| Gene ID | 4807 |
|---|---|
| Other Names | Helix-loop-helix protein 1, HEN-1, Class A basic helix-loop-helix protein 35, bHLHa35, Nescient helix loop helix 1, NSCL-1, NHLH1, BHLHA35, HEN1 |
| Target/Specificity | This NHLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-67 amino acids from the Central region of human NHLH1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NHLH1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NHLH1 |
|---|---|
| Synonyms | BHLHA35, HEN1 |
| Function | May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM].
References
Manetopoulos, C., et al. Biochem. Biophys. Res. Commun. 307(4):891-899(2003)
Bao, J., et al. Development 127(2):425-435(2000)
Lipkowitz, S., et al. J. Biol. Chem. 267(29):21065-21071(1992)
Brown, L., et al. Proc. Natl. Acad. Sci. U.S.A. 89(18):8492-8496(1992)
Begley, C.G., et al. Proc. Natl. Acad. Sci. U.S.A. 89(1):38-42(1992)
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