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TSFM Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P43897 |
| Other Accession | P43896, NP_001166167.1, NP_005717.3 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35391 Da |
| Antigen Region | 253-282 aa |
| Gene ID | 10102 |
|---|---|
| Other Names | Elongation factor Ts, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03135}, EF-Ts {ECO:0000255|HAMAP-Rule:MF_03135}, EF-TsMt {ECO:0000255|HAMAP-Rule:MF_03135}, TSFM {ECO:0000255|HAMAP-Rule:MF_03135} |
| Target/Specificity | This TSFM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the C-terminal region of human TSFM. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TSFM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSFM {ECO:0000255|HAMAP-Rule:MF_03135} |
|---|---|
| Function | Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.
References
Wang, W., et al. Nucleic Acids Res. (2010) In press :
Smeitink, J.A., et al. Am. J. Hum. Genet. 79(5):869-877(2006)
Antonicka, H., et al. Hum. Mol. Genet. 15(11):1835-1846(2006)
Vernon, J.L., et al. Cytogenet. Cell Genet. 89 (3-4), 145-146 (2000) :
Xin, H., et al. J. Biol. Chem. 270(29):17243-17249(1995)
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