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RASSF7 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q02833 |
| Other Accession | NP_001137466.1, NP_003466.1, NP_001137465.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39945 Da |
| Antigen Region | 326-354 aa |
| Gene ID | 8045 |
|---|---|
| Other Names | Ras association domain-containing protein 7, HRAS1-related cluster protein 1, RASSF7, C11orf13, HRC1 |
| Target/Specificity | This RASSF7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-354 amino acids from the C-terminal region of human RASSF7. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RASSF7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RASSF7 |
|---|---|
| Synonyms | C11orf13, HRC1 |
| Function | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with gamma-tubulin |
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Provided below are standard protocols that you may find useful for product applications.
Background
RASSF7 contains 1 Ras-associating domain. It is a centrosome-associated protein required to form a spindle and complete mitosis in the neural tube. There are two isoforms.
References
Recino, A., et al. Biochem. J. 430(2):207-213(2010)
Lescai, F., et al. Eur. J. Hum. Genet. 17(11):1515-1519(2009)
Sherwood, V., et al. Mol. Biol. Cell 19(4):1772-1782(2008)
Tsang, H.T., et al. Genomics 88(3):333-346(2006)
Iarmolinskii, D.G., et al. Tsitol. Genet. 38(1):9-14(2004)
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