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SNRNP70 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P08621 |
| Other Accession | Q62376, Q1RMR2, NP_003080.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51557 Da |
| Antigen Region | 195-223 aa |
| Gene ID | 6625 |
|---|---|
| Other Names | U1 small nuclear ribonucleoprotein 70 kDa, U1 snRNP 70 kDa, U1-70K, snRNP70, SNRNP70, RNPU1Z, RPU1, SNRP70, U1AP1 |
| Target/Specificity | This SNRNP70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human SNRNP70. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SNRNP70 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNRNP70 |
|---|---|
| Synonyms | RNPU1Z, RPU1, SNRP70, U1AP1 |
| Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). |
| Cellular Location | Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250|UniProtKB:Q62376} |
Provided below are standard protocols that you may find useful for product applications.
Background
SNRNP70 mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
References
Spiluttini, B., et al. J. Cell. Sci. 123 (PT 12), 2085-2093 (2010) :
Tzang, B.S., et al. J. Biomed. Sci. 17, 40 (2010) :
Parente Costa, L., et al. J. Autoimmun. 33(2):121-124(2009)
Hernandez, H., et al. PLoS ONE 4 (9), E7202 (2009) :
Palafox Sanchez, C.A., et al. Arthritis Res. Ther. 11 (1), R27 (2009) :
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