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CCNK Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75909 |
| Other Accession | O88874, NP_001092872.1, F1QMB9 |
| Reactivity | Human |
| Predicted | Zebrafish, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64240 Da |
| Antigen Region | 27-54 aa |
| Gene ID | 8812 |
|---|---|
| Other Names | Cyclin-K, CCNK, CPR4 |
| Target/Specificity | This CCNK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-54 amino acids from the N-terminal region of human CCNK. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCNK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCNK |
|---|---|
| Synonyms | CPR4 |
| Function | Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed. Highest levels in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.
References
Marsaud, V., et al. Mol. Cancer 9, 103 (2010) :
Baek, K., et al. J. Mol. Biol. 366(2):563-573(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
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