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SERINC3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13530 |
| Other Accession | Q9QZI9, NP_945179.1, NP_006802.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52580 Da |
| Antigen Region | 373-400 aa |
| Gene ID | 10955 |
|---|---|
| Other Names | Serine incorporator 3, Tumor differentially expressed protein 1, SERINC3, DIFF33, TDE1 |
| Target/Specificity | This SERINC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-400 amino acids from the C-terminal region of human SERINC3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SERINC3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERINC3 (HGNC:11699) |
|---|---|
| Function | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP-dependent, non- specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity (PubMed:37474505). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9QZI9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9QZI9} |
| Tissue Location | Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
SERINC3 may be involved in cellular transformation.
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Bossolasco, M., et al. Oncogene 25(33):4549-4558(2006)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Bossolasco, M., et al. Mol. Carcinog. 26(3):189-200(1999)
Adams, M.D., et al. Nature 377 (6547 SUPPL), 3-174 (1995) :
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