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VDAC3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, FC, IHC-P-Leica, E |
|---|---|
| Primary Accession | Q9Y277 |
| Other Accession | Q9TT13, Q29380, Q60931, Q9MZ13, NP_005653.3, NP_001129166.1 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine, Pig, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30659 Da |
| Antigen Region | 156-183 aa |
| Gene ID | 7419 |
|---|---|
| Other Names | Voltage-dependent anion-selective channel protein 3, VDAC-3, hVDAC3, Outer mitochondrial membrane protein porin 3, VDAC3 |
| Target/Specificity | This VDAC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-183 amino acids from the Central region of human VDAC3. |
| Dilution | IHC-P~~1:100 WB~~1:1000 FC~~1:25 IHC-P-Leica~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VDAC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VDAC3 (HGNC:12674) |
|---|---|
| Function | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:31935282). Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (PubMed:31935282). Involved in male fertility and sperm mitochondrial sheath formation (By similarity). |
| Cellular Location | Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21796}. Membrane Note=May localize to non-mitochondrial membranes |
| Tissue Location | Expressed in erythrocytes (at protein level) (PubMed:27641616). Widely expressed. Highest in testis (PubMed:9781040). |
Provided below are standard protocols that you may find useful for product applications.
Background
VDAC3 belongs to a group of mitochondrial membrane channels involved in translocation of adenine nucleotides through the outer membrane. These channels may also function as a mitochondrial binding site for hexokinase (see HK1; MIM 142600) and glycerol kinase (GK; MIM 300474) (Rahmani et al., 1998).[supplied by OMIM].
References
Reina, S., et al. FEBS Lett. 584(13):2837-2844(2010)
Lefievre, L., et al. Proteomics 7(17):3066-3084(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
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