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METAP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P53582 |
| Other Accession | Q5ZIM5, A6QLA4, Q8BP48, NP_055958.2 |
| Reactivity | Human |
| Predicted | Mouse, Bovine, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43215 Da |
| Antigen Region | 188-216 aa |
| Gene ID | 23173 |
|---|---|
| Other Names | Methionine aminopeptidase 1 {ECO:0000255|HAMAP-Rule:MF_03174}, MAP 1 {ECO:0000255|HAMAP-Rule:MF_03174}, MetAP 1 {ECO:0000255|HAMAP-Rule:MF_03174}, 341118 {ECO:0000255|HAMAP-Rule:MF_03174}, Peptidase M 1 {ECO:0000255|HAMAP-Rule:MF_03174}, METAP1, KIAA0094 |
| Target/Specificity | This METAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-216 amino acids from the Central region of human METAP1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | METAP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | METAP1 |
|---|---|
| Synonyms | KIAA0094 |
| Function | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. |
| Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03174}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
METAP1 removes the amino-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.
References
Xiao, Q., et al. Biochemistry 49(26):5588-5599(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)
Hu, X.V., et al. Biochemistry 46(44):12833-12843(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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