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NUDT4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NZJ9 |
| Other Accession | Q99MY2, Q8R2U6, NP_950241.1, A0A024RBG1 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20306 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 11163 |
|---|---|
| Other Names | Diphosphoinositol polyphosphate phosphohydrolase 2, DIPP-2, Diadenosine 5', 5'''-P1, P6-hexaphosphate hydrolase 2, 361-, Nucleoside diphosphate-linked moiety X motif 4, Nudix motif 4, NUDT4, DIPP2, KIAA0487 |
| Target/Specificity | This NUDT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NUDT4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NUDT4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NUDT4 (HGNC:8051) |
|---|---|
| Synonyms | DIPP2, KIAA0487 |
| Function | Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568). Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates (PubMed:10777568). Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (PubMed:12370170). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing.
References
Fortna, A., et al. PLoS Biol. 2 (7), E207 (2004) :
Fisher, D.I., et al. J. Biol. Chem. 277(49):47313-47317(2002)
Leslie, N.R., et al. BMC Biochem. 3, 20 (2002) :
Caffrey, J.J., et al. Gene 269 (1-2), 53-60 (2001) :
Caffrey, J.J., et al. J. Biol. Chem. 275(17):12730-12736(2000)
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