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NKX3-1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q99801 |
| Other Accession | NP_006158.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26350 Da |
| Antigen Region | 3-1 aa |
| Gene ID | 4824 |
|---|---|
| Other Names | Homeobox protein Nkx-31, Homeobox protein NK-3 homolog A, NKX3-1, NKX31, NKX3A |
| Target/Specificity | This NKX3-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-187 amino acids from the C-terminal region of human NKX3-1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NKX3-1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NKX3-1 (HGNC:7838) |
|---|---|
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11137288} |
| Tissue Location | Highly expressed in the prostate and, at a lower level, in the testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.
References
Kim, S.T., et al. Prostate 70(16):1729-1738(2010)
Takata, R., et al. Nat. Genet. 42(9):751-754(2010)
Gurel, B., et al. Am. J. Surg. Pathol. 34(8):1097-1105(2010)
Bowen, C., et al. Cancer Res. 70(8):3089-3097(2010)
Kunderfranco, P., et al. PLoS ONE 5 (5), E10547 (2010) :
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