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SALL1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NSC2 |
| Other Accession | Q9ER74, NP_001121364.1, NP_002959.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 140405 Da |
| Antigen Region | 11-40 aa |
| Gene ID | 6299 |
|---|---|
| Other Names | Sal-like protein 1, Spalt-like transcription factor 1, Zinc finger protein 794, Zinc finger protein SALL1, Zinc finger protein Spalt-1, HSal1, Sal-1, SALL1, SAL1, ZNF794 |
| Target/Specificity | This SALL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human SALL1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SALL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SALL1 |
|---|---|
| Synonyms | SAL1, ZNF794 |
| Function | Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9ER74}. |
| Tissue Location | Highest levels in kidney. Lower levels in adult brain (enriched in corpus callosum, lower expression in substantia nigra) and liver |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene.
References
Yamamoto, C., et al. Hypertens. Res. 33(2):143-148(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Ramdas, W.D., et al. PLoS Genet. 6 (6), E1000978 (2010) :
Lu, J., et al. PLoS ONE 4 (5), E5577 (2009) :
de Celis, J.F., et al. Int. J. Dev. Biol. 53 (8-10), 1385-1398 (2009) :
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