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REXO2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y3B8 |
| Other Accession | NP_056338.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26833 Da |
| Antigen Region | 129-157 aa |
| Gene ID | 25996 |
|---|---|
| Other Names | Oligoribonuclease, mitochondrial, 31--, RNA exonuclease 2 homolog, Small fragment nuclease, REXO2, SFN, SMFN |
| Target/Specificity | This REXO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-157 amino acids from the Central region of human REXO2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | REXO2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | REXO2 |
|---|---|
| Synonyms | SFN, SMFN |
| Function | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:23741365, PubMed:30926754, PubMed:31588022, PubMed:32365187). Binds and degrades longer oligonucleotides with a lower affinity (PubMed:30926754, PubMed:31588022, PubMed:32365187). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:30926754, PubMed:31588022, PubMed:32365187). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (By similarity). |
| Cellular Location | Mitochondrion intermembrane space. Mitochondrion matrix. Mitochondrion. Cytoplasm. Nucleus |
| Tissue Location | Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Nucleases are components of DNA and RNA metabolism that carry out functions in DNA repair, replication, and recombination and in RNA processing and degradation. SFN is a homolog of Orn, a 3-prime-to-5-prime exoribonuclease of E. coli that attacks the free 3-prime hydroxyl group on single-stranded RNA, releasing 5-prime mononucleotides in a sequential manner.
References
Young Park, A., et al. Protein Expr. Purif. 57(2):180-187(2008)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Ito, S., et al. Photochem. Photobiol. 80(2):281-285(2004)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
Nguyen, L.H., et al. J. Biol. Chem. 275(34):25900-25906(2000)
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