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NECAB2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z6G3 |
| Other Accession | NP_061938.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43194 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 54550 |
|---|---|
| Other Names | N-terminal EF-hand calcium-binding protein 2, EF-hand calcium-binding protein 2, Neuronal calcium-binding protein 2, Synaptotagmin-interacting protein 2, Stip-2, NECAB2, EFCBP2 |
| Target/Specificity | This NECAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NECAB2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NECAB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NECAB2 |
|---|---|
| Synonyms | EFCBP2 |
| Function | May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:F1LQY6, ECO:0000250|UniProtKB:Q91ZP9}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1LQY6}. Cell projection, axon {ECO:0000250|UniProtKB:F1LQY6}. Cell membrane Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity) {ECO:0000250|UniProtKB:F1LQY6, ECO:0000269|PubMed:17689978, ECO:0000269|PubMed:19694902, ECO:0000269|PubMed:26843217} |
| Tissue Location | Expressed in brain. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons and in ependymal cells (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Canela, L., et al. J. Neurochem. 111(2):555-567(2009)
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
Canela, L., et al. Mol. Cell. Neurosci. 36(1):1-12(2007)
Lim, J., et al. Cell 125(4):801-814(2006)
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