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SOX7 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BT81 |
| Other Accession | P40646, NP_113627.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42197 Da |
| Antigen Region | 310-339 aa |
| Gene ID | 83595 |
|---|---|
| Other Names | Transcription factor SOX-7, SOX7 |
| Target/Specificity | This SOX7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the C-terminal region of human SOX7. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SOX7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOX7 |
|---|---|
| Function | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Cytoplasm |
| Tissue Location | Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway.
References
Zhang, Y., et al. Cancer Lett. 277(1):29-37(2009)
Semb, H. Cell Stem Cell 3(4):355-356(2008)
Guo, L., et al. Mol. Cancer Res. 6(9):1421-1430(2008)
Seguin, C.A., et al. Cell Stem Cell 3(2):182-195(2008)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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