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KCTD13 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WZ19 |
| Other Accession | Q7TPL3, Q922M3, Q9H3F6, Q5EAX2, Q7TNY1, O70479, Q13829, Q5F3E8, Q8BGV7, Q2T9W0, NP_849194.1, A9ULR9 |
| Reactivity | Human |
| Predicted | Bovine, Zebrafish, Mouse, Chicken, Rat, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36357 Da |
| Antigen Region | 229-258 aa |
| Gene ID | 253980 |
|---|---|
| Other Names | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1, hBACURD1, BTB/POZ domain-containing protein KCTD13, Polymerase delta-interacting protein 1, TNFAIP1-like protein, KCTD13, BACURD1, PDIP1, POLDIP1 |
| Target/Specificity | This KCTD13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-258 amino acids from the C-terminal region of human KCTD13. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCTD13 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCTD13 |
|---|---|
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in a wide variety of tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
References
Chen, Y., et al. Mol. Cell 35(6):841-855(2009)
Tomaru, T., et al. Endocrinology 147(1):377-388(2006)
Zhou, J., et al. J. Exp. Zoolog. Part A Comp. Exp. Biol. 303(3):227-240(2005)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Kutsenko, A.S., et al. Nucleic Acids Res. 30(14):3163-3170(2002)
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