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COX5B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P10606, P19536, P12075 |
| Other Accession | Q5S3G4, P00428, NP_001853.2, P10606, P19536, P12075 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Antigen Region | 21-49 aa |
| Other Names | Cytochrome c oxidase subunit 5B, mitochondrial, Cytochrome c oxidase polypeptide Vb, COX5B |
|---|---|
| Target/Specificity | This COX5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the Central region of human COX5B. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | COX5B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Provided below are standard protocols that you may find useful for product applications.
Background
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme.
References
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Chen, Z.X., et al. Cell Death Differ. 17(3):408-420(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Beauchemin, A.M., et al. Brain Res. Bull. 56 (3-4), 285-297 (2001) :
Wu, H., et al. J. Biol. Chem. 275(42):32491-32498(2000)
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