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TRIM41 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WV44 |
| Other Accession | NP_963921.1, NP_291027.3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 71670 Da |
| Antigen Region | 567-596 aa |
| Gene ID | 90933 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM41, 632-, RING finger-interacting protein with C kinase, RINCK, Tripartite motif-containing protein 41, TRIM41, RINCK |
| Target/Specificity | This TRIM41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-596 amino acids from the C-terminal region of human TRIM41. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM41 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM41 {ECO:0000303|PubMed:16022281, ECO:0000312|HGNC:HGNC:19013} |
|---|---|
| Function | E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:28169297, PubMed:29899090, PubMed:31979016). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS (PubMed:29760876). Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed in multiple tissues with the highest levels in heart and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TRIM41 belongs to a family of tripartite motif (TRIM) proteins defined as containing a RING finger, one or more B-box domains, and a coiled-coil region (Tanaka et al., 2005 [PubMed 16022281]). See TRIM45 (MIM 609318).
References
Chen, D., et al. J. Biol. Chem. 282(46):33776-33787(2007)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Tanaka, M., et al. Mol. Biol. Rep. 32(2):87-93(2005)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
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