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ZNF346 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UL40 |
| Other Accession | NP_036411.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32933 Da |
| Antigen Region | 188-214 aa |
| Gene ID | 23567 |
|---|---|
| Other Names | Zinc finger protein 346, Just another zinc finger protein, ZNF346, JAZ |
| Target/Specificity | This ZNF346 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-214 amino acids from the Central region of human ZNF346. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZNF346 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF346 |
|---|---|
| Synonyms | JAZ |
| Function | Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins (PubMed:28431233). |
| Cellular Location | Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5 |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.
References
Chen, T., et al. Mol. Cell. Biol. 24(15):6608-6619(2004)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
Yang, M., et al. J. Biol. Chem. 274(39):27399-27406(1999)
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