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OSBPL6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BZF3 |
| Other Accession | NP_665682.1, NP_115912.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 106306 Da |
| Antigen Region | 769-796 aa |
| Gene ID | 114880 |
|---|---|
| Other Names | Oxysterol-binding protein-related protein 6, ORP-6, OSBP-related protein 6, OSBPL6, ORP6 |
| Target/Specificity | This OSBPL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 769-796 amino acids from the C-terminal region of human OSBPL6. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OSBPL6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OSBPL6 |
|---|---|
| Synonyms | ORP6 |
| Function | Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). |
| Cellular Location | Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope. Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum {ECO:0000250|UniProtKB:Q8BXR9} |
| Tissue Location | Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.
References
Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Lehto, M., et al. Cell Tissue Res. 315(1):39-57(2004)
Jaworski, C.J., et al. Genomics 78(3):185-196(2001)
Lehto, M., et al. J. Lipid Res. 42(8):1203-1213(2001)
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