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GGT6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6P531 |
| Other Accession | NP_001116362.1, NP_699169.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50509 Da |
| Antigen Region | 23-49 aa |
| Gene ID | 124975 |
|---|---|
| Other Names | Gamma-glutamyltransferase 6, GGT 6, Gamma-glutamyltranspeptidase 6, Glutathione hydrolase 6, Gamma-glutamyltransferase 6 heavy chain, Gamma-glutamyltransferase 6 light chain, GGT6 |
| Target/Specificity | This GGT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-49 amino acids from the N-terminal region of human GGT6. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GGT6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GGT6 (HGNC:26891) |
|---|---|
| Function | Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:P19440}; Single- pass type II membrane protein {ECO:0000250|UniProtKB:P07314} |
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Provided below are standard protocols that you may find useful for product applications.
Background
GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).
References
Heisterkamp, N., et al. Hum. Genet. 123(4):321-332(2008)
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