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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > GPR32 Antibody (N-term)
GPR32 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75388 |
| Other Accession | NP_001497.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40087 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 2854 |
|---|---|
| Other Names | Probable G-protein coupled receptor 32, GPR32 |
| Target/Specificity | This GPR32 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GPR32. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR32 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR32 |
|---|---|
| Function | G-protein coupled receptor that binds to several ligands including resolvin D1 (RvD1) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. In macrophages, enhances the RvD1-stimulated phagocytic and clearance functions (PubMed:20080636). Macrophages migrate less toward different chemoattractant stimuli but phagocytose more microbial particles (PubMed:26969756). Prevents the increase in Ca(2+) and activation of ERK1/2 used by histamine and its H1 receptor subtype to induce goblet cell secretion by activating PKC and GRK2 to counter-regulate the histamine receptor (PubMed:23462912). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed in resting primary human macrophages. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
GPR32 is an Orphan receptor.
References
Krishnamoorthy, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(4):1660-1665(2010)
Marchese, A., et al. Genomics 50(2):281-286(1998)
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$ 192.50
$ 75.00
Cat# AP17488a
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