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CACNB3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P54284 |
| Other Accession | P54287, P54286, P54285, NP_000716.2 |
| Reactivity | Human |
| Predicted | Mouse, Rabbit, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54532 Da |
| Antigen Region | 407-434 aa |
| Gene ID | 784 |
|---|---|
| Other Names | Voltage-dependent L-type calcium channel subunit beta-3, CAB3, Calcium channel voltage-dependent subunit beta 3, CACNB3, CACNLB3 |
| Target/Specificity | This CACNB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-434 amino acids from the C-terminal region of human CACNB3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CACNB3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CACNB3 |
|---|---|
| Synonyms | CACNLB3 {ECO:0000303|PubMed:7557998} |
| Function | Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed mostly in brain, colon and ovary. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
References
Zhang, Y., et al. J. Biol. Chem. 285(4):2527-2536(2010)
Bernardo, J.F., et al. Can. J. Physiol. Pharmacol. 87(7):522-530(2009)
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Vendel, A.C., et al. J. Neurosci. 26(10):2635-2644(2006)
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