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ALS2CL Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q60I27 |
| Other Accession | NP_001177636.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 107748 Da |
| Antigen Region | 349-377 aa |
| Gene ID | 259173 |
|---|---|
| Other Names | ALS2 C-terminal-like protein, ALS2CL |
| Target/Specificity | This ALS2CL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-377 amino acids from the Central region of human ALS2CL. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ALS2CL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALS2CL |
|---|---|
| Function | Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. |
| Cellular Location | Cytoplasm. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells |
| Tissue Location | Expressed in heart and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ALS2CL acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.
References
Suzuki-Utsunomiya, K., et al. Biochem. Biophys. Res. Commun. 354(2):491-497(2007)
Hadano, S., et al. FEBS Lett. 575 (1-3), 64-70 (2004) :
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