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SRPR Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P08240 |
| Other Accession | Q3MHE8, NP_001171313.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 69811 Da |
| Antigen Region | 453-480 aa |
| Gene ID | 6734 |
|---|---|
| Other Names | Signal recognition particle receptor subunit alpha, SR-alpha, Docking protein alpha, DP-alpha, SRPR |
| Target/Specificity | This SRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-480 amino acids from the C-terminal region of human SRPR. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SRPR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SRPRA (HGNC:11307) |
|---|---|
| Synonyms | SRPR |
| Function | Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32916}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32916}; Cytoplasmic side {ECO:0000250|UniProtKB:P32916}. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain. {ECO:0000250|UniProtKB:P32916} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants.
References
Janin, N., et al. Hum. Genet. 88(5):583-585(1992)
Hortsch, M., et al. Biochem. Biophys. Res. Commun. 150(1):111-117(1988)
Hortsch, M., et al. Nucleic Acids Res. 16(1):361-362(1988)
Tajima, S., et al. J. Cell Biol. 103(4):1167-1178(1986)
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