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ZCCHC8 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6NZY4 |
| Other Accession | NP_060082.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 78577 Da |
| Antigen Region | 560-590 aa |
| Gene ID | 55596 |
|---|---|
| Other Names | Zinc finger CCHC domain-containing protein 8, TRAMP-like complex RNA-binding factor ZCCHC8, ZCCHC8 |
| Target/Specificity | This ZCCHC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 560-590 amino acids from the C-terminal region of human ZCCHC8. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZCCHC8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZCCHC8 |
|---|---|
| Function | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non- coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). |
| Cellular Location | Nucleus, nucleoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Note=Excluded from nucleolus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ZCCHC8 may be involved in pre-mRNA splicing.
References
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Gustafson, M.P., et al. Biochem. Biophys. Res. Commun. 338(3):1359-1367(2005)
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