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SUDS3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H7L9 |
| Other Accession | Q8BR65, A6H6W9, NP_071936.2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38136 Da |
| Antigen Region | 72-98 aa |
| Gene ID | 64426 |
|---|---|
| Other Names | Sin3 histone deacetylase corepressor complex component SDS3, 45 kDa Sin3-associated polypeptide, Suppressor of defective silencing 3 protein homolog, SUDS3, SAP45, SDS3 |
| Target/Specificity | This SUDS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-98 amino acids from the N-terminal region of human SUDS3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SUDS3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SUDS3 |
|---|---|
| Synonyms | SAP45, SDS3 |
| Function | Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in various cancer cell ines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).
References
Silveira, A.C., et al. Cancer Lett. 276(1):32-37(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Hurst, D.R., et al. Biochem. Biophys. Res. Commun. 348(4):1429-1435(2006)
Fleischer, T.C., et al. Mol. Cell. Biol. 23(10):3456-3467(2003)
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