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UPK3B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BT76 |
| Other Accession | NP_085047.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33882 Da |
| Antigen Region | 192-219 aa |
| Gene ID | 105375355 |
|---|---|
| Other Names | Uroplakin-3b, UP3b, Uroplakin IIIb, UPIIIb, p35, UPK3B |
| Target/Specificity | This UPK3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-219 amino acids from the Central region of human UPK3B. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UPK3B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UPK3B |
|---|---|
| Function | Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER) |
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Provided below are standard protocols that you may find useful for product applications.
Background
UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM].
References
Foot, N.J., et al. Blood 112(10):4268-4275(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Garcia-Espana, A., et al. Mol. Phylogenet. Evol. 41(2):355-367(2006)
Deng, F.M., et al. J. Cell Biol. 159(4):685-694(2002)
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