DCTN6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O00399 |
Other Accession | NP_006562.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 20747 Da |
Antigen Region | 53-80 aa |
Gene ID | 10671 |
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Other Names | Dynactin subunit 6, Dynactin subunit p27, Protein WS-3, DCTN6, WS3 |
Target/Specificity | This DCTN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-80 amino acids from the Central region of human DCTN6. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DCTN6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DCTN6 (HGNC:16964) |
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Synonyms | WS3 |
Function | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. |
Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:D0G6S1}. Chromosome, centromere, kinetochore |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Parisi, G., et al. FEBS Lett. 562 (1-3), 1-4 (2004) :
Eckley, D.M., et al. J. Cell Biol. 147(2):307-320(1999)
Murdock, D.G., et al. J. Biol. Chem. 274(20):14429-14433(1999)
Ichikawa, K., et al. Gene 189(2):277-287(1997)
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