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PHF20L1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | A8MW92 |
| Other Accession | NP_115581.3, NP_940915.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 115010 Da |
| Antigen Region | 912-940 aa |
| Gene ID | 51105 |
|---|---|
| Other Names | PHD finger protein 20-like protein 1, PHF20L1 |
| Target/Specificity | This PHF20L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 912-940 amino acids from the C-terminal region of human PHF20L1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PHF20L1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PHF20L1 |
|---|---|
| Function | Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity). |
| Cellular Location | Nucleus. Note=Localized to the perinucleolar region |
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Provided below are standard protocols that you may find useful for product applications.
Background
PHF20L1 (PHD finger protein 20-like 1) is a 554 amino acid protein that contains two tudor domains and is expressed as multiple alternatively spliced isoforms.
References
Kimura, K., et al. Genome Res. 16(1):55-65(2006)
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