RNF165 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q6ZSG1 |
Other Accession | E9QAU8, NP_689683.2 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 39526 Da |
Antigen Region | 3-31 aa |
Gene ID | 494470 |
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Other Names | RING finger protein 165, RNF165 |
Target/Specificity | This RNF165 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-31 amino acids from the N-terminal region of human RNF165. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RNF165 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ARK2C (HGNC:31696) |
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Synonyms | RNF165 |
Function | E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:E9QAU8}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Pickard, B.S., et al. Psychiatr. Genet. 15(1):37-44(2005)
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