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HNRPLL Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WVV9 |
| Other Accession | Q921F4, NP_612403.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60083 Da |
| Antigen Region | 132-162 aa |
| Gene ID | 92906 |
|---|---|
| Other Names | Heterogeneous nuclear ribonucleoprotein L-like, hnRNPLL, Stromal RNA-regulating factor, HNRNPLL, HNRPLL, SRRF |
| Target/Specificity | This HNRPLL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-162 amino acids from the N-terminal region of human HNRPLL. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HNRPLL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HNRNPLL |
|---|---|
| Synonyms | HNRPLL, SRRF |
| Function | RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. |
| Tissue Location | Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).
References
Wu, Z., et al. J. Immunol. 185(1):231-238(2010)
Topp, J.D., et al. RNA 14(10):2038-2049(2008)
Oberdoerffer, S., et al. Science 321(5889):686-691(2008)
Lim, J., et al. Cell 125(4):801-814(2006)
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
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