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LYPLA2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95372 |
| Other Accession | Q9QYL8, Q9WTL7, NP_009191.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24737 Da |
| Antigen Region | 181-207 aa |
| Gene ID | 11313 |
|---|---|
| Other Names | Acyl-protein thioesterase 2, APT-2, 312-, Lysophospholipase II, LPL-II, LysoPLA II, LYPLA2, APT2 |
| Target/Specificity | This LYPLA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-207 amino acids from the C-terminal region of human LYPLA2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LYPLA2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LYPLA2 |
|---|---|
| Synonyms | APT2 |
| Function | Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha- glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1- arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in various breast cancer cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq].
References
Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
Wang, A., et al. Biochim. Biophys. Acta 1439(1):1-16(1999)
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