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RQCD1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q92600 |
| Other Accession | Q6IP65, Q5PQL2, Q9JKY0, Q4R347, Q6NWL4, A7MB47, NP_005435.1 |
| Reactivity | Human |
| Predicted | Bovine, Zebrafish, Monkey, Mouse, Rat, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33631 Da |
| Antigen Region | 106-134 aa |
| Gene ID | 9125 |
|---|---|
| Other Names | Cell differentiation protein RCD1 homolog, Rcd-1, CCR4-NOT transcription complex subunit 9, RQCD1, CNOT9, RCD1 |
| Target/Specificity | This RQCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the Central region of human RQCD1. |
| Dilution | WB~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RQCD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNOT9 (HGNC:10445) |
|---|---|
| Synonyms | RCD1, RQCD1 |
| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9JKY0}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250|UniProtKB:Q9JKY0} |
| Tissue Location | Detected in spleen, thymus, prostate, testis, ovary and intestine. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor that down-regulates MYB-and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A.
References
Ajiro, M., et al. Int. J. Oncol. 35(4):673-681(2009)
Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)
Garapaty, S., et al. J. Biol. Chem. 283(11):6806-6816(2008)
Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007)
Hiroi, N., et al. EMBO J. 21(19):5235-5244(2002)
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