DHRS1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q96LJ7 |
Other Accession | NP_001129522.1, NP_612461.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 33909 Da |
Antigen Region | 183-209 aa |
Gene ID | 115817 |
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Other Names | Dehydrogenase/reductase SDR family member 1, 11--, DHRS1 |
Target/Specificity | This DHRS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-209 amino acids from the Central region of human DHRS1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DHRS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DHRS1 (HGNC:16445) |
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Synonyms | SDR19C1 |
Function | NADPH-dependent oxidoreductase which catalyzes the reduction of steroids (estrone, androstene-3,17-dione and cortisone) as well as prostaglandin E1, isatin and xenobiotics in vitro (PubMed:30031147). May have a role in steroid and/or xenobiotic metabolism (PubMed:30031147). |
Cellular Location | Endoplasmic reticulum. Note=May be attached to the ER membrane by its C-terminus segment. |
Tissue Location | Detected in heart, liver, adrenal glands, and at low levels in skeletal muscle, kidney, pancreas and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, have been identified.
References
Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :
Wu, Q., et al. Mol. Biol. Rep. 28(4):193-198(2001)
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