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MSC Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O60682 |
| Other Accession | NP_005089.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22068 Da |
| Antigen Region | 166-194 aa |
| Gene ID | 9242 |
|---|---|
| Other Names | Musculin, Activated B-cell factor 1, ABF-1, Class A basic helix-loop-helix protein 22, bHLHa22, MSC, ABF1, BHLHA22 |
| Target/Specificity | This MSC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the C-terminal region of human MSC. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MSC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MSC |
|---|---|
| Synonyms | ABF1, BHLHA22 |
| Function | Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in lymphoid tissues, B-cell lines and activated B-cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq].
References
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Ushmorov, A., et al. Leukemia 22(10):1942-1944(2008)
Knight, J.C., et al. Nat. Genet. 36(4):394-399(2004)
Wong, J., et al. DNA Cell Biol. 20(8):465-471(2001)
Robb, L., et al. Genomics 57(2):318-319(1999)
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