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RAB2B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WUD1 |
| Other Accession | P59279, NP_116235.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24214 Da |
| Antigen Region | 105-131 aa |
| Gene ID | 84932 |
|---|---|
| Other Names | Ras-related protein Rab-2B, RAB2B |
| Target/Specificity | This RAB2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-131 amino acids from the Central region of human RAB2B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RAB2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB2B (HGNC:20246) |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}; Cytoplasmic side {ECO:0000250|UniProtKB:P59279}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}; Cytoplasmic side {ECO:0000250|UniProtKB:P59279}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}; Cytoplasmic side {ECO:0000250|UniProtKB:P59279}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P59279}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}; Cytoplasmic side {ECO:0000250|UniProtKB:P59279}. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid. {ECO:0000250|UniProtKB:P59279} |
| Tissue Location | Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM].
References
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Fu, G.K., et al. Genomics 84(1):205-210(2004)
Ni, X., et al. J. Hum. Genet. 47(10):548-551(2002)
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