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ACCN5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NY37 |
| Other Accession | NP_059115.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57464 Da |
| Antigen Region | 388-414 aa |
| Gene ID | 51802 |
|---|---|
| Other Names | Acid-sensing ion channel 5, ASIC5, Amiloride-sensitive cation channel 5, Human intestine Na(+) channel, HINaC, ASIC5, ACCN5, HINAC |
| Target/Specificity | This ACCN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 388-414 amino acids from the C-terminal region of human ACCN5. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ACCN5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASIC5 (HGNC:17537) |
|---|---|
| Function | Forms bile acid-gated sodium channels and may play a role in bile acid-dependent absorption and secretion by epithelial cells of the bile ducts (PubMed:10767424, PubMed:22735174). Displays high selectivity for sodium ions but can also permit the permeation of other cations (Probable). The gating could be indirect and the consequence of alterations of the membrane environment of the channel by bile acids (By similarity). As a sodium channel of type II unipolar brush cells of the vestibulocerebellum, controlling the electrical activity of these cells, could play a role in motor coordination and balance (By similarity). |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:Q9R0W5}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known.
References
Schaefer, L., et al. FEBS Lett. 471 (2-3), 205-210 (2000) :
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