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KCNF1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H3M0 |
| Other Accession | NP_002227.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55584 Da |
| Antigen Region | 195-221 aa |
| Gene ID | 3754 |
|---|---|
| Other Names | Potassium voltage-gated channel subfamily F member 1, Voltage-gated potassium channel subunit Kv51, kH1, KCNF1 |
| Target/Specificity | This KCNF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-221 amino acids from the Central region of human KCNF1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCNF1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNF1 (HGNC:6246) |
|---|---|
| Function | Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q14721}; Multi-pass membrane protein |
| Tissue Location | Detected in heart, brain, liver, skeletal muscle, kidney and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq].
References
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Ottschytsch, N., et al. Proc. Natl. Acad. Sci. U.S.A. 99(12):7986-7991(2002)
Su, K., et al. Biochem. Biophys. Res. Commun. 241(3):675-681(1997)
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