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ADM2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z4H4 |
| Other Accession | NP_079142.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 15865 Da |
| Antigen Region | 15-42 aa |
| Gene ID | 79924 |
|---|---|
| Other Names | ADM2, Intermedin, Adrenomedullin-2, AM2, Intermedin-long, IMDL, Intermedin-short, IMDS, ADM2, AM2 |
| Target/Specificity | This ADM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-42 amino acids of human ADM2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADM2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADM2 (HGNC:28898) |
|---|---|
| Synonyms | AM2 |
| Function | Intermedin/ADM2 is a peptide hormone that plays a role as physiological regulator of gastrointestinal and cardiovascular bioactivities mediated by the CALCRL-RAMPs receptor complexes (PubMed:14615490). Activates the cAMP-dependent pathway through interaction with CALCRL-RAMP3 receptor complex (PubMed:14615490). |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
ADM2 belongs to a family of calcitonin (MIM 114130)-related peptide hormones important for regulating diverse physiologic functions and the chemical composition of fluids and tissues.
References
Cai, Y., et al. Cardiovasc. Res. 85(4):864-873(2010)
Pfeil, U., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 297 (5), L837-L845 (2009) :
Chauhan, M., et al. Biol. Reprod. 81(4):777-783(2009)
Smith, R.S. Jr., et al. Am. J. Physiol. Heart Circ. Physiol. 297 (3), H1040-H1047 (2009) :
Pearson, L.J., et al. Cell. Physiol. Biochem. 23 (1-3), 97-108 (2009) :
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