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R4RL2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86UN3 |
| Other Accession | NP_848665.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46106 Da |
| Antigen Region | 279-308 aa |
| Gene ID | 349667 |
|---|---|
| Other Names | Reticulon-4 receptor-like 2, Nogo receptor-like 3, Nogo-66 receptor homolog 1, Nogo-66 receptor-related protein 2, NgR2, RTN4RL2 (HGNC:23053) |
| Target/Specificity | This R4RL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279-308 amino acids from the C-terminal region of human R4RL2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | R4RL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RTN4RL2 (HGNC:23053) |
|---|---|
| Function | Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7M6Z0}. Perikaryon {ECO:0000250|UniProtKB:Q80WD1}. Cell projection, axon {ECO:0000250|UniProtKB:Q80WD1}. Note=Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses. {ECO:0000250|UniProtKB:Q7M6Z0} |
| Tissue Location | Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
RTN4RL2 may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
References
Lee, H., et al. J. Neurosci. 28(11):2753-2765(2008)
Taylor, T.D., et al. Nature 440(7083):497-500(2006)
Walmsley, A.R., et al. Biochem. Biophys. Res. Commun. 327(1):112-116(2005)
Lauren, J., et al. Mol. Cell. Neurosci. 24(3):581-594(2003)
Barton, W.A., et al. EMBO J. 22(13):3291-3302(2003)
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