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HLA-DMB Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P28068 |
| Other Accession | NP_002109.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28931 Da |
| Antigen Region | 127-154 aa |
| Gene ID | 3109 |
|---|---|
| Other Names | HLA class II histocompatibility antigen, DM beta chain, MHC class II antigen DMB, Really interesting new gene 7 protein, HLA-DMB, DMB, RING7 |
| Target/Specificity | This HLA-DMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-154 amino acids from the Central region of human HLA-DMB. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HLA-DMB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HLA-DMB |
|---|---|
| Synonyms | DMB, RING7 |
| Function | Plays a critical role in catalyzing the release of class II- associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. |
| Cellular Location | Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes |
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Provided below are standard protocols that you may find useful for product applications.
Background
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
References
Rinderknecht, C.H., et al. Immunology 131(1):18-32(2010)
Bailey, S.D., et al. Diabetes Care (2010) In press :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Ferrante, A., et al. J. Immunol. 184(3):1153-1158(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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