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NOVA2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UNW9 |
| Other Accession | NP_002507.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49009 Da |
| Antigen Region | 87-114 aa |
| Gene ID | 4858 |
|---|---|
| Other Names | RNA-binding protein Nova-2, Astrocytic NOVA1-like RNA-binding protein, Neuro-oncological ventral antigen 2, NOVA2, ANOVA, NOVA3 |
| Target/Specificity | This NOVA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-114 amino acids from the N-terminal region of human NOVA2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NOVA2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOVA2 (HGNC:7887) |
|---|---|
| Synonyms | ANOVA, NOVA3 |
| Function | Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion (PubMed:32197073). It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons (PubMed:10811881). Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'- YCAY-3' cluster enhances spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Uniquely regulates alternative splicing events of a series of axon guidance related genes during cortical development, being essential for central nervous system development by regulating neural networks wiring. Regulates differentially alternative splicing on the same transcripts expressed in different neurons. This includes functional differences in transcripts expressed in cortical and cerebellar excitatory versus inhibitory neurons where is required for, respectively, development of laminar structure and motor coordination and synapse formation. Also the regulation the regulation of intron retention can sequester the trans-acting splicing factor PTBP2, acting as a variable cis-acting scaffolding platform for PTBP2 across various natural conditions (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:A0A1W2P872}. |
| Tissue Location | Brain. Expression restricted to astrocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
NOVA2 may regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.
References
Heinzen, E.L., et al. Am. J. Hum. Genet. 80(5):876-883(2007)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Lewis, H.A., et al. Cell 100(3):323-332(2000)
Lewis, H.A., et al. Structure 7(2):191-203(1999)
Yang, Y.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 95(22):13254-13259(1998)
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