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NUBPL Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8TB37 |
| Other Accession | NP_079428.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34083 Da |
| Antigen Region | 40-67 aa |
| Gene ID | 80224 |
|---|---|
| Other Names | Iron-sulfur protein NUBPL, IND1 homolog, Nucleotide-binding protein-like, huInd1, NUBPL, C14orf127 |
| Target/Specificity | This NUBPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-67 amino acids from the N-terminal region of human NUBPL. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NUBPL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NUBPL |
|---|---|
| Synonyms | C14orf127 |
| Function | Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:19752196). May deliver one or more Fe-S clusters to complex I subunits (PubMed:19752196). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Highest expression in liver and kidney. expressed at significant levels in small intestine and brain (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Respiratory complex I (NADH:ubiquinone oxidoreductase EC 1.6.5.3) is a large mitochondrial inner membrane enzyme consisting of 45 subunits and 8 iron-sulfur (Fe/S) clusters. NUBPL, or IND1, is an Fe/ S protein that plays a critical role in the assembly of respiratory complex I, likely by transferring Fe/S into the Fe/S-containing complex I subunits (Sheftel et al., 2009 [PubMed 19752196]).
References
Calvo, S.E., et al. Nat. Genet. 42(10):851-858(2010)
Sheftel, A.D., et al. Mol. Cell. Biol. 29(22):6059-6073(2009)
Volpi, S., et al. Mol. Psychiatry 14(11):1024-1031(2009)
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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