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SASS6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6UVJ0 |
| Other Accession | Q80UK7, NP_919268.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 74397 Da |
| Antigen Region | 325-352 aa |
| Gene ID | 163786 |
|---|---|
| Other Names | Spindle assembly abnormal protein 6 homolog, HsSAS-6, SASS6, SAS6 |
| Target/Specificity | This SASS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-352 amino acids from the Central region of human SASS6. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SASS6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SASS6 (HGNC:25403) |
|---|---|
| Synonyms | SAS6 |
| Function | Central scaffolding component of the centrioles ensuring their 9-fold symmetry (By similarity). Required for centrosome biogenesis and duplication: required both for mother-centriole- dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:15665853, PubMed:16244668, PubMed:17681131). Not required for centriole formation in embryonic stem cells but necessary to maintain centriole architecture (By similarity). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). Overexpression results in excess foci-bearing centriolar markers (PubMed:15665853). |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis {ECO:0000250|UniProtKB:Q80UK7} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007) [PubMed 17681132].
References
Tang, C.J., et al. Nat. Cell Biol. 11(7):825-831(2009)
Strnad, P., et al. Dev. Cell 13(2):203-213(2007)
Kleylein-Sohn, J., et al. Dev. Cell 13(2):190-202(2007)
Habedanck, R., et al. Nat. Cell Biol. 7(11):1140-1146(2005)
Leidel, S., et al. Nat. Cell Biol. 7(2):115-125(2005)
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